GLUCOCORTICOID STIMULATION OF THE BIOSYNTHESIS OF GLUTAMIC-ALANINE TRANSAMINASE
نویسندگان
چکیده
منابع مشابه
Glucocorticoid Stimulation of the Biosynthesis of Glutamic-alanine Transaminase.
Among the mechanisms which have been considered as possible descriptions of the molecular events underlying hormone action, one which has attracted increasing attention among contemporary biochemists is the proposal that control of the biosynthesis of specific enzymes may be an important factor (see, e.g., ref. 1). The plethora of enzyme activities which are found to increase or decrease in res...
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It has now been clearly established that pyridoxal phosphate serves as the coenayme of many transaminases. Several lines of evidence have indicated that the coenzyme acts alternately as acceptor and donar of amino groups, shuttling between the aldehydic (pyridoxal phosphate) and amino (pyridoxamine phosphate) forms (2-11). However, a detailed study of the kinetics of the transaminase reaction w...
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Because of the general nature of the transamination reaction (1, 2), a study of the kinetics and mechanism of reaction seemed of interest. Preliminary studies of this nature have already appeared (3-5). However, these studies were carried out with crude extracts or resolved enzyme systems. In order to conduct a critical kinetic study as well as a study of the mechanism of reaction, large amount...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1963
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.50.5.912